Principal Investigator
Christel Vérollet (CR1/INSERM)
• Team of Isabelle Maridonneau-Parini (DR1/INSERM), “Phagocyte migration and differentiation”, IPBS/CNRS, Toulouse, FRANCE
• Website: http://www.ipbs.fr/index.php/member/christel-verollet
Co-principal Investigator
Geanncarlo Lugo-Villarino (CRCN/CNRS)
• Team of Olivier Neyrolles (DR1/CNRS), “Mycobacterial Interactions with Host Cells”, IPBS/CNRS
• Website: http://www.ipbs.fr/index.php/member/geanncarlo-lugo-villarino
Title of the Project
Cellular and molecular mechanisms involved in tuberculosis-mediated exacerbation of HIV-1 infection in macrophages: focus on Siglec-1 and tunneling nanotubes
Context and Project
Co-infection with Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), and HIV-1 is major health issue in the world. The synergistic relationship between HIV-1 and Mtb is known to result in increased pathogen proliferation and associated pathogenesis. In this context, we recently demonstrated that tunneling nanotubes (TNT) are cellular structures induced by a TB-associated microenvironment that favors HIV-1 spread among macrophages, enhancing virus load as observed in HIV/TB co-infected patients.
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