Protein-protein interactions : Fungal Hsp90
Fungal Hsp90 chaperone is a major regulator of cell wall integrity and virulence. Genetic impairment of Hsp90 function reduces tolerance to stress and abrogates drug resistance to the two main classes of antifungals (azoles and echinocandins). Inhibition of Hsp90 by geldanamycin restores susceptibility of C. albicans strains resistant to azoles and echinocandins but such ATP inhibitors appear to have limited therapeutic potential on their own as they exhibit in vivo toxicity because of their non-selectivity.
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