Un champignon associé au cancer du pancréas…

Un champignon associé au cancer du pancréas…

Une nouvelle étude révèle que certains champignons sont capables de passer de l’intestin au pancréas. Dans ce contexte, leur population augmente plus de mille fois et favorise la progression du cancer du pancréas. Publié dans la revue Nature le mois dernier, l’étude est la première à proposer des preuves solides que le mycobiome (le mélange local d’espèces fongiques) peut provoquer dans le pancréas des changements physiologiques qui mènent à la transformation de cellules saines en adénocarcinome pancréatique. Redoutée des services d’oncologie, cette forme de cancer est généralement mortelle dans les deux ans. Menée chez des souris et chez des patients atteints d’un cancer du pancréas, l’étude a révélé que certaines espèces de champignons, en particulier appartenant au genre Malassezia, pénétraient dans le pancréas par le canal pancréatique, un tube par lequel les sucs digestifs se déversent dans les intestins, et favoriseraient l’oncogenèse. Dirigée par des chercheurs de la School of Medicine et du College of Dentistry de L’Université de New York, l’étude a également révélé que le traitement des souris avec un puissant antifongique réduisait de 20 à 40% le poids de leur tumeur au cours des 30 dernières semaines. Alors que les virus, les bactéries et les parasites étaient déjà reconnus comme facteurs de causalité dans les processus de cancérogénèse, aucune étude antérieure n’avait associé de champignons au cancer du pancréas.

Reference :
Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma, Yuqi Guo, Anjana Saxena, Mridula Vardhan, Brian Diskin, Wei Wang, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Mautin Hundeyin, Constantinos Zambrinis, Xin Li, Deepak Saxena, George Miller. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature, 2019; DOI: 10.1038/s41586-019-1608-2

 

Nicolas PAPON nicolas.papon@univ-angers.fr
Christophe DENFERT christophe.denfert@pasteur.fr

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